Vancomycin levels are frequently subtherapeutic during continuous venovenous hemodialysis (CVVHD)
نویسندگان
چکیده
Continuous renal replacement therapy (CRRT) is frequently used in the intensive care setting for the treatment of acute kidney injury. Dosing guidelines for many commonly used antibiotics were established during intermittent dialysis or in studies examining CRRT at lower blood and dialysis flow rates than are used in common practice. Herein we present data demonstrating frequent subtherapeutic levels of vancomycin in a population of patients on CRRT. Nephrology trainees should be educated as to the risks of under-dosing antibiotics in this population.
منابع مشابه
گزارش سه مورد CVVHD) Continous Venovenous Hemodialysis)
Some of ICU patients with Acute Renal Failure (ARF) require dialysis. Conventional or intermittent hemodialysis (HD) may cause hypotension and insufficient loss of fluids and toxins from blood. Peritoneal dialysis also my cause peritonitis and has lower efficiency than HD. We did continuous Venovenous Hemodialysis (CVVHD) for three ICU patients with ARF in Saint-Zahra Medical Center for the fir...
متن کاملInitial vancomycin dosing recommendations for critically ill patients undergoing continuous venovenous hemodialysis.
BACKGROUND Delaying appropriate antimicrobial therapy for critically ill patients increases the risk of death. Currently, there are insufficient data to guide initial vancomycin dosing for patients undergoing continuous venovenous hemodialysis (CVVHD). OBJECTIVE To develop practical recommendations for initial dosing of vancomycin, based on the pharmacokinetics of this drug in critically ill ...
متن کاملDeterminants of ceftazidime clearance by continuous venovenous hemofiltration and continuous venovenous hemodialysis.
Although several dosage adjustment regimens have been proposed, there is little quantitative information to guide the initiation of ceftazidime therapy in patients who are receiving continuous renal replacement therapy. To determine the clearance of ceftazidime by continuous venovenous hemofiltration (CVVH) and continuous venovenous hemodialysis (CVVHD), we performed controlled clearance studie...
متن کاملCarbamazepine and the active epoxide metabolite are effectively cleared by hemodialysis followed by continuous venovenous hemodialysis in an acute overdose.
Hemodialysis (HD) and continuous venovenous hemodialysis (CVVHD) have an unproven role in the management of carbamazepine overdose. Albumin-enhanced CVVHD may accelerate carbamazepine (CBZ) clearance, but no pharmacokinetic data has been reported for traditional CVVHD without albumin enhancement. In addition, it is unclear whether the active CBZ-epoxide metabolite is removed with either mode of...
متن کاملPharmacokinetics of piperacillin-tazobactam in anuric intensive care patients during continuous venovenous hemodialysis.
The pharmacokinetics of piperacillin-tazobactam were investigated in eight anuric intensive care patients treated by continuous venovenous hemodialysis (CVVHD). The elimination half-life of piperacillin was 4.3 +/- 1.2 h, and that of tazobactam was 5.6 +/- 1.3 h. The contribution of CVVHD to the overall elimination was relevant (>25%) for both drugs.
متن کامل